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Serodiagnostic value of the 19 kilodalton antigen ofMycobacterium tuberculosis in indian patients

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Abstract

Previous studies in UK subjects suggested that the 19 kDa protein antigen ofMycobacterium tuberculosis might be valuable in the serodiagnosis of paucibacillary tuberculosis. In this study, antibody titres for the 19 kDa antigen were higher in healthy controls in India than in the UK. Consequently, the diagnostic sensitivity of this antigen and its TB23 epitope was negligible in Indian patients with tuberculosis. However, a diagnostic sensitivity of 50 % was achieved in patients with skin tuberculosis on the basis of a high ratio between antibody titres for the whole antigen and its TB23 epitope.

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Authors and Affiliations

  1. MRC Tuberculosis and Related Infections Unit, Hammersmith Hospital, London, UK

    G. Bothamley, H. Batra & J. Ivanyi

  2. Department of Chest Medicine, University College Hospital, Gower St., WC1 E 6AU, London, UK

    G. Bothamley

  3. Safdarjung Hospital, New Delhi, India

    V. Ramesh

  4. National Institute of Mental Health and Neurosciences, Bangalore, India

    A. Chandramui

Authors
  1. G. Bothamley
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  2. H. Batra
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  3. V. Ramesh
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  4. A. Chandramui
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  5. J. Ivanyi
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Bothamley, G., Batra, H., Ramesh, V. et al. Serodiagnostic value of the 19 kilodalton antigen ofMycobacterium tuberculosis in indian patients. Eur. J. Clin. Microbiol. Infect. Dis. 11, 912–915 (1992). https://doi.org/10.1007/BF01962372

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  • DOI: https://doi.org/10.1007/BF01962372

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