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Serum levels of interleukin-1β and interleukin-6 in patients with chronic pancreatitis

  • Liver, Pancreas, and Biliary Tract
  • Published:
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Abstract

To investigate the role played by cytokines in chronic pancreatitis, we examined serum levels of interleukin-1β (IL-1β) and interleukin-6 (IL-6) by radioimmunoassay (RIA) and enzyme-linked immunosorbent assay (ELISA) in 33 patients with definitively diagnosed chronic pancreatitis. All the patients, who had received either no treatment or only digestive enzyme products for their chronic pancreatitis, had significantly elevated serum IL-1β levels (38.5±28.8pg/ml, mean ± SD), compared to normal controls (16.0±6.7pg/ml;P<0.01); however they showed no changes in serum IL-6 levels. Changes in IL-1β and IL-6 serum levels were not correlated with the etiological features of pancreatitis or with complications due to liver diseases. Serum IL-1β and IL-6 levels were also not correlated with the activity of any pancreatic enzymes in blood or urine. However, in the patients with chronic pancreatitis, serum IL-6 levels were correlated with C-reactive protein (CRP), whereas serum IL-1β levels were not correlated with CRP or with erythrocyte sedimentation rate. These results suggest that serum IL-1β is involved in the progression and reduction of chronic inflammation of the pancreas, and that the serum IL-1β level may be useful as a marker for chronic pancreastitis.

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Authors and Affiliations

  1. The Second Department of Internal Medicine, Shiga University of Medical Science, Tsukinowa, Seta, 520-1, Ohtsu, Shiga, Japan

    Tadao Bamba, Utako Yoshioka, Hisayuki Inoue, Yoshiaki Iwasaki & Shiro Hosoda

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  1. Tadao Bamba
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  2. Utako Yoshioka
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  3. Hisayuki Inoue
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  4. Yoshiaki Iwasaki
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  5. Shiro Hosoda
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Bamba, T., Yoshioka, U., Inoue, H. et al. Serum levels of interleukin-1β and interleukin-6 in patients with chronic pancreatitis. J Gastroenterol 29, 314–319 (1994). https://doi.org/10.1007/BF02358371

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  • DOI: https://doi.org/10.1007/BF02358371

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