Abstract
In this review we discuss the effects of interleukin-2 (IL-2) therapy on trafficking of leukocytes and platelets to normal organs. The use of animal models has allowed the elucidation of events leading to damage and/or dysfunction of normal tissues after IL-2 administration. These studies have shown that acute toxicity induced by IL-2 is mediated primarily by neutrophils. Chronic toxicity results from the adhesion and transmigration of activated lymphocytes into normal organs. Platelet-derived microvascular thrombosis also contributes to the vascular toxicity of IL-2. A better understanding of these mechanisms may lead to the development of interventions that will significantly improve the therapeutic efficacy of IL-2.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 22 August 1998 / Accepted: 16 October 1998
Rights and permissions
About this article
Cite this article
Lentsch, A., Miller, F. & Edwards, M. Mechanisms of leukocyte-mediated tissue injury induced by interleukin-2. Cancer Immunol Immunother 47, 243–248 (1999). https://doi.org/10.1007/s002620050527
Issue Date:
DOI: https://doi.org/10.1007/s002620050527