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Prognostic implication of p27 expression in primary central nervous system lymphoma

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Abstract

To clarify the role of p27/Kip1 (p27) in primary central nervous system lymphomas (PCNSLs), we examined p27 expression by immunohistochemical methods in a series of 22 patients with PCNSL. We attempted to correlate the expression of p27 with proliferation potential and prognosis. Although the MIB-1 labeling index (LI) was lower in tumors with low p27 expression (26.7% ± 17.2% vs 38.1% ± 16.3%), it was not significantly different from that of tumors with high p27 expression (P = 0.1253). Survival analysis revealed that high p27 expression was significantly associated with poorer overall prognosis (P = 0.0011); however, the MIB-1 LI were not associated with prognosis. Our results suggest p27 as a predictor of prognosis in patients with PCNSL.

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Authors and Affiliations

  1. Department of Neurosurgical Surgery, Kagawa University, Kagawa, Japan

    Katsuzo Kunishio & Seigo Nagao

  2. Department of Neurosurgery, Kawasaki Medical School, Kawasaki Hospital, 2-1-80 Nakasange, Okayama, 700-8505, Japan

    Katsuzo Kunishio

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  1. Katsuzo Kunishio
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  2. Seigo Nagao
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Correspondence to Katsuzo Kunishio.

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Kunishio, K., Nagao, S. Prognostic implication of p27 expression in primary central nervous system lymphoma. Brain Tumor Pathol 23, 77–81 (2006). https://doi.org/10.1007/s10014-006-0206-9

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  • DOI: https://doi.org/10.1007/s10014-006-0206-9

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