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IgG4-Related Sclerosing Disease: A Novel Mimic of Inflammatory Bowel Disease

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Abstract

High levels of IgG4-positive plasma cells are commonly seen in autoimmune pancreatitis. It has recently become evident that autoimmune pancreatitis is one component of a larger multi-system disease. IgG4-positive plasma cells have been identified in many extrapancreatic tissues, including the colon, biliary tract, liver, and lungs, and thus the term “IgG4-related sclerosing disease” has been proposed. Awareness of IgG4-related sclerosing disease is important, as it has been shown to mimic other conditions like malignancy. This review discusses IgG4-related colitis and its potential for mimicking inflammatory bowel disease.

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Correspondence to John K. Marshall.

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Narula, N., Vasudev, M. & Marshall, J.K. IgG4-Related Sclerosing Disease: A Novel Mimic of Inflammatory Bowel Disease. Dig Dis Sci 55, 3047–3051 (2010). https://doi.org/10.1007/s10620-010-1287-1

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  • DOI: https://doi.org/10.1007/s10620-010-1287-1

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