Clinical studyType and distribution of pulmonary parenchymal and vascular amyloid: Correlation with cardiac amyloidosis☆
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2022, Respiratory MedicineCitation Excerpt :Although systemic ATTR primarily involves heart and peripheral nerve tissue, many other tissue types are affected including the pulmonary parenchyma and vasculature [7]. Multiple studies have described the spectrum of pulmonary manifestations in patients with amyloid light chain (AL) amyloidosis, but very little is known about lung involvement in ATTR outside of individual case reports and autopsies, and the antemortem diagnosis of pulmonary ATTR is increasing with more widespread use of chest imaging and lung biopsy [8–11]. The aim of this retrospective single-center study was to investigate the clinical, pathologic, and radiologic manifestations of pulmonary ATTR.
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This study was supported by Grants HL-14153 and P50-HL-17655-04 from The National Institutes of Health, Public Health Service, Department of Health, Education and Welfare.
- 1
From the Departments of Pathology, Oncology and Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland.