General obstetrics and gynecology
Confined placental mosaicism and intrauterine growth retardation: A case-control analysis of placentas at delivery

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Abstract

OBJECTIVE: Our purpose was to determine the frequency of confined placental mosaicism in newborns with unexplained infrauterine growth retardation compared with infants with appropriate in utero growth.

STUDY DESIGN: Amnion, chorion, and villi from 12 growth-retarded infants and 24 appropriately grown, matched controls were karyotyped. Fluorescence in situ hybridization with chromosome-specific probes was then used to confirm the karyotypic abnormality at additional uncultured placental sites.

RESULTS: Karyotype analysis revealed placental mosaicism involving either aneuploidy or polyploidy in three of 12 (25%) cases versus two of 24 (8.3%) controls. Fluorescence in situ hybridization confirmed the caryotypic abnormalities in the placentas from growth-retarded infants only.

CONCLUSION: Confined placental mosaicism was identified three times more frequently from placentas of growth-retarded infants compared with those of newborns with appropriate growth. Molecular studies of the placentas suggested a wider distribution of cells with abnormal karyotypes in cases compared with controls and support a biologic influence of placental mosaicism on fetal growth.

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    Supported in part by the William Randolph Hearst Fund at Harvard Medical School.

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