Correlation of estrogen, progesterone, and androgen receptors in breast cancer

doi:10.1016/0002-9610(89)90704-6

The American Journal of Surgery

Volume 157, Issue 6, June 1989, Pages 577-580

https://doi.org/10.1016/0002-9610(89)90704-6 Get rights and content

Abstract

Breast cancer was induced in female Holtzman rats by intragastric administration of 7,12-dimethylbenz[a] antracene (DMBA). At tumor maturity, biopsies of viable tissue were obtained, frozen, and then assayed for estrogen, progesterone, and androgen receptor content. By simple linear regression analysis, progesterone receptor levels significantly correlated with both estrogen and androgen receptor levels, whereas estrogen and androgen receptor levels did not correlate with each other. Multiple regression analyses further substantiated the predictive value of the progesterone receptor for the other two hormone receptors. Knowledge of breast tumor androgen receptor levels may further enhance the value of the estrogen receptor and progesterone receptor in hormonal responsiveness. Further, the progesterone receptor may be the most sensitive of the steroid hormone receptors for selecting patients likely to respond to hormonal therapy.

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¹: From the Departments of Surgery and Food Science and Human Nutrition, University of Florida, Gainesville, Florida.

²: From the Department of Biochemistry, University of Louisville School of Medicine, Louisville, Kentucky.

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Scientific paperCorrelation of estrogen, progesterone, and androgen receptors in breast cancer

Abstract

Eur J Cancer Clin Oncol

Anal Biochem

J Surg Res

Biochim Biophys Acta

Eur J Cancer

The value of estrogen and progesterone receptors in the treatment of breast cancer

Cancer

Influence of tumor estrogen and progesterone receptor levels on the response of tamoxifen and chemotherapy in primary breast cancer

J Clin Oncol

Steroid receptors and response to endocrine ablations in women with metastatic cancer of the breast

Cancer

Progesterone receptors as a prognostic factor in stage II breast cancer

N Engl J Med

The role of progesterone receptors in the management of advanced breast cancer

Cancer

The clinical value of multiple steroid receptor assays in breast cancer management

Cancer

The predictive value of estrogen and progesterone receptors' concentration on the clinical behavior of breast cancer in women

Cancer

The prognostic value of estrogen determinations in patients with primary breast cancer: an update

Cancer

Treatment of primary breast cancer with chemotherapy and tamoxifen

N Engl J Med

Scientific paper
Correlation of estrogen, progesterone, and androgen receptors in breast cancer