A palm oil-enriched diet lowers serum lipoprotein(a) in normocholesterolemic volunteers
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Cited by (40)
Lipoprotein(a) and diet—a challenge for a role of saturated fat in cardiovascular disease risk reduction?
2023, American Journal of Clinical NutritionNon-genetic influences on lipoprotein(a) concentrations
2022, AtherosclerosisCitation Excerpt :We will also summarize evidence on pathological conditions that modify Lp(a) levels, including kidney and liver diseases, emphasizing the magnitude and directionality of their effects as pertinent to cardiovascular risk as well as the apo(a) size polymorphism (for a summary, see Box 1). One of the first human clinical trial evidence that diet may modulate Lp(a) concentration was reported by Hornstra et al. [5] who observed a 10% reduction in Lp(a) concentration with a palm-oil enriched diet compared to a control Dutch diet. In further support of an impact of fat quality, a 23% increase in Lp(a) concentration was seen in response to a high oleic-acid diet with ∼10% compared to a diet with 19% of calories from saturated fatty acids (SFA) [6].
Venous thrombosis risk: Effects of palm oil and hydrogenated fat diet in rats
2011, NutritionCitation Excerpt :Palm oil (PO), a rich source of both palmitic acid (C16:0, 44.3%), a saturated fatty acid, and monounsaturated fatty acids (MUFA) (C18:1, 39.0%) [12], is notably growing in popularity and use in the food industry for several functional reasons (e.g., inherent stability, resistance to oxidation) and it can be used without hydrogenation because of its semisolid texture at room temperature [13]. With its unsaturated-to-saturated fatty acid ratio close to 1 and its high content of antioxidant vitamins, PO has been pointed out for its beneficial effects in reducing the risk of arterial thrombosis and atherosclerosis [14–16]. Müller et al. [17] demonstrated that a diet rich in trans fatty acid has a more unfavorable effect on postprandial tissue plasminogen activator activity than one rich in palmitic acid, which has been shown to correlate with a decrease in HDL cholesterol.