Research paperRelation of serum homocysteine and lipoprotein(a) concentrations to atherosclerotic disease in a prospective Finnish population based study
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2016, World NeurosurgeryCitation Excerpt :The combined model improved the ability of those biomarkers in predicting DVT risk compared with those alone (AUC of the combined model, 0.96; 95% CI, 0.93–0.98; P < 0.01). There was previous evidence regarding the association between high plasma Lp(a) levels and atherosclerotic disease,18,19 but only limited data are available on their effects on VTE. An Lp(a) is closely homologous with plasminogen,20 so that reduced fibrinolysis is considered to be the link between increased Lp(a) levels and thrombosis.
Lipoprotein (a) as a cause of cardiovascular disease: Insights from epidemiology, genetics, and biology
2016, Journal of Lipid ResearchLipoprotein (a) as a risk factor for ischemic stroke: A meta-analysis
2015, AtherosclerosisCitation Excerpt :Pooled analysis of 4 studies [27,47,48,56] that reported data in women yielded a lower RR (pooled estimated OR = 1.49; 95% CI = 1.09–2.04; Q = 3.44; p = 0.39; I2 = 12.72%; see eFigure 3A in the supplement). Subgroup analysis of six prospective studies [25,50,51,59,60,62] that reported sex-specific data resulted in a pooled adjusted RR of 1.49 (95% CI = 1.10–2.03; Q = 12.18; p = 0.02; I2 = 67.15%) for women. There was moderate heterogeneity.