Review article and viewpointLp(a) lipoprotein in cardiovascular disease
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Increase of serum lipoprotein (a), an adverse effect of growth hormone treatment
2022, Growth Hormone and IGF ResearchCitation Excerpt :Taken together, the presented data demonstrates that not only high GH such as in acromegaly but also low doses of daily GH administration increases circulating Lp(a). Acromegaly with high circulating GH is associated with a high incidence of ASCVD and twice the death rate compared with the general population [64,65]. It is also characterized by very high serum Lp(a) level.
Association between lipoprotein(a) and nonalcoholic fatty liver disease among Korean adults
2016, Clinica Chimica ActaCitation Excerpt :Lipoprotein(a) [Lp(a)] is an LDL-like particle synthesized by the liver that contains an apolipoprotein B100 molecule covalently linked to a plasminogen-like glycoprotein, apolipoprotein(a) [apo(a)], by disulfide bridges [1,2]. Previous studies have demonstrated that increased Lp(a) concentrations is an important cardiovascular risk factor [3–6]. Although metabolic syndrome (MetS) and type 2 diabetes are also cardiovascular risk factors, the relationship between Lp(a) concentrations and MetS and type 2 diabetes remains controversial.
Lipoprotein (a) as a cause of cardiovascular disease: Insights from epidemiology, genetics, and biology
2016, Journal of Lipid ResearchCardiovascular risk in rheumatoid arthritis: How to lower the risk?
2013, AtherosclerosisCitation Excerpt :Lp(a), which is a pro-atherogenic lipoprotein that consists of an LDL-like particle and apo(a), can become oxidized and provoke an immune response similar to oxLDL. Apo(a) promotes thrombosis and inhibits fibrinolysis due to its homology with plasminogen [19,20]. An increase in Lp(a) has also been associated with inflammation, but data are inconsistent [21–23].
Lipoprotein (a) is independently correlated with coronary artery calcification
2013, European Journal of Internal Medicine