Symposia
The measurement of hormones in saliva: Possibilities and pitfalls

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Abstract

The easy stress-free, non-invasive nature of saliva collection makes it one of the most accessible body fluids and it is potentially of value in studying normal human physiology as well as pathology. Measurements of salivary hormone levels will usually only be of value if they reflect the plasma level of the hormone and the relationship between the saliva and plasma levels of many hormones have been studied by a number of groups. The measurement of the salivary level is a valuable clinical tool for some hormones (e.g. Cortisol, oestriol, progesterone), is of little value for others (e.g. cortisone, dehydroepiandrosterone sulphate, thyroxine, pituitary hormones) and for many others the saliva/plasma relationship is not yet sufficiently understood to assess the value of the salivary measurement. As well as reviewing the state of our knowledge of the salivary concentration of many hormones this review outlines a number of “rules of thumb” concerning the presence of hormones in saliva, their saliva/plasma relationship and the potential usefulness of assays of their salivary concentration.

References (79)

  • M. Luisi et al.

    Radioimmunoassay tor progesterone in human saliva during the menstrual cycle

    J. steroid Biochem.

    (1981)
  • J.R. Zorn et al.

    Salivary progesterone as an index of the luteal function

    Fertil. Steril.

    (1984)
  • B.M. Lippe et al.

    Serum 17-alpha-hydroxyprogesterone, progesterone, estradiol and testosterone in the diagnosis and management of congenital adrenal hyperplasia

    J. Pediat.

    (1974)
  • D.A. Price et al.

    Assay of hydroxyprogesterone in saliva (letter)

    Lancet

    (1979)
  • R.F. Vining et al.

    Hormones in saliva

    CRC Crit. Rev. clin. Lab. Sci.

    (1985)
  • G. Cimasoni
  • S.J. Challacombe et al.

    Passage of immunoglobulins from plasma to the oral cavity in rhesus monkeys

    Immunology

    (1978)
  • J.A. Young et al.

    Transport in salivary and salt glands

  • C. Lentner
  • F.G. Oppenheimer

    Preliminary observation on the presence and origins of serum albumin on human saliva

    Helv. odont. Acta

    (1970)
  • W. Fischer-Rasmussen et al.

    Salivary total oestriol through normal pregnancy and some clinical aspects of oestriol determinations

  • M. Luisi et al.

    Salivary steroid measurement: an alternative approach to plasma assays in assessing endocrine function. Front

    Front oral Physiol.

    (1984)
  • D.K. Mason et al.

    Salivary Glands in Health and Disease

    (1975)
  • R.F. Vining et al.

    Hormones in saliva: mode of entry and consequent implications for clinical interpretation

    Clin. Chem.

    (1983)
  • R.F. Walker et al.

    Radioimmunoassay of 17-alpha-hydroxy-progesterone in saliva, parotid fluid, and plasma of congenital adrenal hyperplasia patients

    Clin. Chem.

    (1979)
  • J. Landon et al.

    The assay of salivary cortisol

  • A.S. Burgen

    The secretion of non-electrolytes in the parotid saliva

    J. Cell. comp. Physiol.

    (1956)
  • K. Martin et al.

    Changes in the permeability of the salivary gland caused by sympathetic stimulation and by catecholamines

    J. gen. Physiol.

    (1962)
  • Y. Hirata et al.

    Epidermal growth factor (urogastrone) in human fluids: size heterogeneity

    J. clin. Endocr. Metab.

    (1979)
  • A.O. Turkes et al.

    Determination of androstenedione in saliva

  • R. McVie et al.

    The biologic significance of the aldosterone concentration in saliva

    Pediat. Res.

    (1979)
  • R.F. Walker et al.

    Salivary Cortisol: I. Monitoring changes in normal adrenal activity

  • P.E. Cusick et al.

    Influence of sampling time on salivary oestriol concentrations in pregnant women

    Ann. clin. Biochem.

    (1984)
  • D. Riad-Fahmy

    Salivary progesterone for investigating ovarian activity

    Front, oral Physiol.

    (1984)
  • J. Few

    Discussion

  • R.F. Walker et al.

    Adrenal status assessed by direct radioimmunoassay of cortisol in whole saliva or parotid saliva

    Clin. Chem.

    (1978)
  • R.F. Vining et al.

    Salivary cortisol: a better measure of adrenal cortical function than serum cortisol

    Ann clin. Biochem.

    (1983)
  • J.R. Peters et al.

    Salivary cortisol assays for assessing pituitary-adrenal reserve

    clin. Endocr., Oxf.

    (1982)
  • J. Guechot et al.

    Physiological and pathological variations in saliva cortisol

    Horm. Res.

    (1982)

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