Short communicationIntegration of human papillomavirus type 16 into cellular DNA of cervical carcinoma: Preferential deletion of the E2 gene and invariable retention of the long control region and the E6/E7 open reading frames
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Understanding the HPV integration and its progression to cervical cancer
2018, Infection, Genetics and EvolutionCitation Excerpt :E6 and E7 genes products have shown to be primarily responsible for the cellular transformation process (Takebe et al., 1987; Cripe et al., 1987; Vousden et al., 1988; Hakura et al., 1989). It has been proposed that the integration of HPV into the host genome occurs following a break in the E2 gene, which has been described as the main repressor of the expression of the E6 and E7 oncogenes (Choo et al., 1987b; zur Hausen, 2009). This break results in the loss of repression of these oncogenes, whose proteins interfere with the function of cellular proteins p53 and pRb, respectively.
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