Original contributionIsolated atrial amyloidosis: A clinicopathologic study indicating increased prevalence in chronic heart disease
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Cited by (40)
Age-related cardiovascular changes and diseases
2022, Cardiovascular PathologyMolecular imaging of atrial myopathy: Towards early AF detection and non-invasive disease management
2022, Trends in Cardiovascular MedicineCitation Excerpt :Additional targets would be worthy of investigation. For instance, accumulation of insoluble, misfolded proteins could be of considerable interest, since isolated atrial amyloidosis (IAA; classified as atrial cardiomyopathy type IVa), attributed to structural heart diseases, such as rheumatic heart disease (RHD) and atrial septal defects [109], is characterized by focal atrial buildup of extracellular proteinaceous deposits. Furthermore, based on neuropathological evidence that amyloid Aβ40 and Aβ42 proteins are deposited in the cerebral vasculature during cerebral amyloid angiopathy (CAA) [110], molecular imaging of cerebrospinal fluid Aβ40 that accumulates in the heart specifically in AF [111] would provide better management criteria for those AF patients with CAA.
Cardiac amyloidosis: An underdiagnosed/underappreciated disease
2019, European Journal of Internal MedicineCitation Excerpt :Despite the presence of LVH, the ECG may show low-voltage QRS complexes in variable percentages (~45% in AL CM, ~30% in ATTRwt and 16–45% in ATTRm) [53]; pseudo-infarction pattern with poor R-wave progression and/or pathologic Q waves may be seen in ~two-thirds of cases, and AF in ~one-third of patients [18,65]. As mentioned, atrial amyloidosis probably related to atrial natriuretic peptide amyloid fibril deposits has been reported as a frequent histological finding as detected in atrial appendage specimens obtained from patients with AF and rheumatic or other cardiac diseases [66–68]. Echocardiography is the principal diagnostic tool for cardiac amyloidosis [69].
EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: Definition, characterization, and clinical implication
2017, Heart RhythmCitation Excerpt :Isolated atrial amyloidosis is also linked to structural heart disease. In atrial biopsies from 167 patients undergoing cardiac surgery, 23 of 26 amyloid-positive specimens were from patients with rheumatic heart disease (RHD), while the remaining 3 came from patients with atrial septal defects.80 The overall incidence of 16% was greater than that was seen in control atrial autopsy specimens from trauma victims (3%).
EHRA/HRS/APHRS/SOLAECE expert consensus on Atrial cardiomyopathies: Definition, characterisation, and clinical implication
2016, Journal of ArrhythmiaCitation Excerpt :The PV atrial reversal velocity has also been used as a measurement of LA function [317,377,379–382]. In the presence of reduced LV compliance and elevated filling pressures, atrial contraction results in significant flow reversal into the PVs [80,81]. Studies have also demonstrated that Doppler tissue imaging can be used as an accurate marker of atrial function [383,384].
Age-related Cardiovascular Changes and Diseases
2016, Cardiovascular Pathology: Fourth Edition