Original contributionLocalization of hyaluronan in normal breast tissue, radial scar, and tubular breast carcinoma☆
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Cited by (43)
Molecular weight specific impact of soluble and immobilized hyaluronan on CD44 expressing melanoma cells in 3D collagen matrices
2017, Acta BiomaterialiaCitation Excerpt :However, the application of defined presentation modes and the quantitative adhesion measurements in our study suggest different modes of CD44 dependent HA internalization and highly different strength of receptor-ligand interaction as possible reasons for the different effects of LMW-HA and HMW-HA as observed in various studies [21,67,68]. The importance to distinguish the different effects of immobilized and soluble HA is furthermore supported by the fact, that soluble HA can be found in blood and in the lymphatic circulation, as well as at degraded tissue and tumor ECM in contrast to its presentation in an immobilized form in the ECM [82,83]. In light of our results on a partially inverse relationship of soluble and covalently immobilized LMW-HA on invasion and proliferation for CD44+ BRO melanoma cells multiple cell behaviors can be expected for the various physiological and pathological conditions.
Computer-aided diagnosis of breast cancer using cytological images: A systematic review
2016, Tissue and CellCitation Excerpt :The most prevalent types of BC are Invasive Ductal Carcinoma, Ductal Carcinoma in situ, and Invasive lobular carcinoma (Borst and Ingold, 1993; Li et al., 2005). Some other types of BC include Mucinous carcinoma (Saha et al., 2016), Tubular carcinoma, Metaplastic Carcinoma, Medullary carcinoma and Micropapillary carcinoma, etc. (Rapin et al., 1988; de la Torre et al., 1993; Cardenosa et al., 1994). An overview of the pathogenesis of a BC metastasis is represented in Fig. 1.
TGFβ and matrix-regulated epithelial to mesenchymal transition
2014, Biochimica et Biophysica Acta - General SubjectsCitation Excerpt :During tumor progression the ECM composition and structure are modified by infiltrating mast cells, leukocytes, macrophages and “activated” fibroblasts that release growth factors, cytokines, chemotactic factors and proteolytic enzymes and exhibit increased biosynthetic activity of ECM components. In particular, elevated production of the ECM components hyaluronan, versican and collagen is prominent in breast tumor stroma [18–22]. In breast cancer, the ECM is enriched in many new constituents, mainly proteins such as specific collagen and fibronectin isoforms and secreted growth factors such as transforming growth factor β (TGFβ) and fibroblast growth factors (FGFs) that have an impact on the tumor cells by facilitating the onset and maintenance of EMT.
Hyaluronan synthase 2 (HAS2) promotes breast cancer cell invasion by suppression of tissue metalloproteinase inhibitor 1 (TIMP-1)
2011, Journal of Biological ChemistryCitation Excerpt :Hyaluronan-activated CD44 signaling has been shown to enhance oncogenic events induced by growth factors and MMPs, and CD44 can form complexes with growth factor receptors, as well as with MMPs (10, 12, 17–19). The expression of hyaluronan synthases (HAS1, HAS2, and HAS3) increases during embryonic development, as well as during malignant progression, specifically in nests of cancer cells and at the invading edges of breast carcinomas (20–23). Of the three HAS genes, HAS2 is vital because of its involvement in epithelial-mesenchymal transition during embryonic cardiac cushion morphogenesis (24).
Pathology of B3 lesions of the breast
2009, Diagnostic HistopathologyCitation Excerpt :The histological resemblance between tubular carcinoma and the entrapped epithelial elements in the central zone of RS/CSL, together with the observation that these tumours have been observed to arise in association with RS/CSL,57,60 lends weight to the former theory. Similar levels of the extracellular matrix component hyaluronic acid have been found in tubular carcinomas and RS/CSL,63 reflecting the stromal derangements seen in these two conditions and further supporting their association. RS/CSL has also been postulated as an independent marker of increased risk for subsequent development of carcinoma.
Hyaluronan in Human Tumors: Importance of Stromal and Cancer Cell-Associated Hyaluronan
2009, Hyaluronan in Cancer Biology
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Supported by grants from the Swedish Cancer Society.