PaperImmunohistochemistry of vascular lesion in thrombotic thrombocytopenic purpura, with special reference to factor VIII related antigen
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2015, Critical Care ClinicsCitation Excerpt :Clinically, the patients present with shock caused by poor perfusion of the organs and petechiae and purpura on the skin. Autopsies in patients who have died with DIC reveal fibrin-rich microthrombi in small and midsize vessels in all organs.2,4,27 Tissue factor plays a key role in the initiation and propagation of DIC.