Cell
MinireviewProgrammed cell death: Apoptosis and oncogenesis
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2016, GeneCitation Excerpt :Currently, there are no effective vaccines available to prevent schistosomiasis (Beaumier et al., 2013), thus control of this disease is largely dependent on treatment with drugs, especially praziquantel (PZQ) (Thetiot-Laurent et al., 2013). Apoptosis, the most prominent form of programmed cell death among multicellular organisms, is executed by a genetically regulated process to maintain ontogenesis and homeostasis (Williams, 1991) and plays a major role in the elimination of unwanted or injured cells and the inhibition of the host inflammatory response (Voll et al., 1997). In schistosomes, previous genomic studies have identified similarities between schistosomes and higher organisms in regard to some apoptotic processes and molecules, although all factors involved in the apoptotic pathway of schistosomes have not yet been clearly identified (Berriman et al., 2009; Zhou et al., 2009).
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