ORIGINAL ARTICLESSignificance of CD44 gene products for cancer diagnosis and disease evaluation
References (12)
- et al.
Clinical imlications of metastatic process
Lancet
(1992) - et al.
Multiple variants of the human lymphocyte homing receptor CD44 generated by insertions at a single site in the extracellular domain
J Biol Chem
(1992) - et al.
A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family
Cell
(1989) - et al.
A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells
Cell
(1991) - et al.
Alternative splicing in the control of gene expression
Annu Rev Genet
(1989)
Cited by (465)
CNTs mediated CD44 targeting; a paradigm shift in drug delivery for breast cancer
2020, Genes and DiseasesCitation Excerpt :However, the expression pattern and extent both play a vital role in drug resistance. In a study, it was reported that cells are having overexpression of CD44v6 treated with standard chemotherapeutic drugs shown significant higher viability and clonogenicity in colon cancer over cells which lacks expression of CD44v6 variants.53 CD44 represents a class of cell surface adhesion glycoprotein plays a vital role in cell–cell interaction.
Multifunctional nanotheranostic gold nanocages for photoacoustic imaging guided radio/photodynamic/photothermal synergistic therapy
2019, Acta BiomaterialiaCitation Excerpt :Therefore, we chose 24 h post-injection of AuNCs-HA to study the in vivo tumor imaging and therapy. It is reported that HA shows targeting capability to CD44-overexpressing breast cancers [39,52]. Therefore, to demonstrate the targeting efficiency of AuNCs-HA, we evaluated the targeting ability of AuNCs-HA by examination of the concentration of Au in tumors treated with AuNCs, AuNCs-PEG or AuNCs-HA using ICP-OES (Fig. S9).
Stimuli-responsive nanoparticles based on co-assembly of naturally-occurring biomacromolecules for in vitro photodynamic therapy
2018, Colloids and Surfaces A: Physicochemical and Engineering AspectsCitation Excerpt :These materials show good biodegradability and high compatibility, as HA can be selectively degraded by hyaluronidases [28]. Especially self-assembled nanoparticles of HA can accumulate in tumors not only through the EPR effect but also through the specific interactions between HA and CD44, a receptor that is overexpressed on various tumor cells [29,30], providing the nanoparticles with favorable tumor-targeting properties. In addition, overexpressed levels of hyaluronidases are found in various tumors [31–34], suggesting, that the loaded drugs can be preferentially released from the nanoparticles inside tumors.
OutSplice: A Novel Tool for the Identification of Tumor-Specific Alternative Splicing Events
2023, BioMedInformatics