Increased nitric oxide synthesis in ulcerative colitis

doi:10.1016/0140-6736(93)90211-X

The Lancet

Volume 341, Issue 8843, 20 February 1993, Pages 465-466

https://doi.org/10.1016/0140-6736(93)90211-X Get rights and content

Abstract

Nitric oxide (NO) is produced in tissues by NO synthase with the liberation of equimolar amounts of citrulline. Citrulline concentrations were significantly higher in rectal biopsy specimens from patients with active ulcerative colitis than in those from patients with quiescent disease or with normal histology. Incubation of biopsy samples from patients with ulcerative colitis with N^G-monomethyl-L-arginine (L-NMMA) inhibited citrulline production. These findings suggest that mucosal NO biosynthesis is increased in active colitis and that NO may have a pathogenic role in ulcerative colitis.

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Citation Excerpt :
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SHORT REPORTSIncreased nitric oxide synthesis in ulcerative colitis

Abstract

Clin Chim Acta

J Chromatogr

Lancet

Colonic circular smooth muscle relaxation by leucocyte derived nitric oxide

Gut

Macrophage oxidation of L-arginine to nitrate and nitrite: nitric oxide is an intermediate

Biochemistry

SHORT REPORTS
Increased nitric oxide synthesis in ulcerative colitis