Benign melanocytic lesions: Risk markers or precursors of cutaneous melanoma?
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Immunotherapy Options for Acral Melanoma, A fast-growing but Neglected Malignancy
2022, Archives of Medical ResearchAssociation between Phenotypic Characteristics and Melanoma in a Large Prospective Cohort Study
2019, Journal of Investigative DermatologyCitation Excerpt :The case-control literature consistently reports stronger associations between high nevus counts and melanoma of the trunk and of actinic damage (as a marker of high cumulative sun exposure) and melanoma of nontrunk sites (Kvaskoff et al., 2013; Olsen et al., 2011), findings that support divergent etiologic pathways for melanomas occurring on highly UVR-exposed versus less UVR-exposed anatomical sites (Whiteman et al., 1998, 2003, 2006). Laboratory studies have also reported consistent differences in molecular and genetic profiles of melanomas occurring on different body sites (Carli et al., 1999; Hacker et al., 2010; Purdue et al., 2005; Skender-Kalnenas et al., 1995; Whiteman et al., 1998). We investigated possible additive interactions for phenotype and sun-exposure variables representing presumed different causal pathways for melanoma.
Factors Related to Nevus-Associated Cutaneous Melanoma: A Case-Case Study
2018, Journal of Investigative DermatologyCitation Excerpt :Converging lines of evidence from epidemiologic and molecular studies suggest that cutaneous melanomas arise through at least two causal pathways: one of which is associated with chronic exposure to sunlight, and the other with host propensity to developing large numbers of melanocytic nevi (Shain and Bastian, 2016; Whiteman et al., 2011). It has long been recognized that a proportion of cutaneous melanomas have evidence of contiguous neval remnants on histologic examination (hereafter referred to as nevus-associated melanomas), although the exact proportion is debated (Haenssle et al., 2016; Marks et al., 1990; Massi et al., 1999; Skender-Kalnenas et al., 1995). A recent meta-analysis of 38 observational studies reported that a summary prevalence estimate of 29.1% of melanomas had adjacent neval remnants, although there was significant heterogeneity across studies (Pampena et al., 2017).
Melanoma Arising in a Melanocytic Nevus
2018, Actas Dermo-SifiliograficasA meta-analysis of nevus-associated melanoma: Prevalence and practical implications
2017, Journal of the American Academy of DermatologyCitation Excerpt :Superficial spreading melanoma was the most frequent histologic subtype, and the trunk and extremities were the most common locations reported in both groups (Supplemental Table II; available at http://www.jaad.org). Of the 38 included studies, only 16 studies for DNM2,4,13,19,20,25-27,29,30,35,39,41,43,45,47 and 1 more study for NAM44 classified melanomas according to Breslow thickness. A higher prevalence of invasive melanoma was reported for both the DNM and NAM groups; however, in situ tumors were slightly more prevalent in the NAM group (408/2057, 19.8%) than the DNM group (727/4995, 14.6%) (Supplemental Table II; available at http://www.jaad.org).
p15 Expression Differentiates Nevus from Melanoma
2016, American Journal of Pathology