Different mutations of the p53 gene in nodule-in-nodule hepatocellular carcinoma as a evidence for multistage progression
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Cited by (51)
Mutations in TP53, CTNNB1 and PIK3CA genes in hepatocellular carcinoma associated with hepatitis B and hepatitis C virus infections
2013, GenomicsCitation Excerpt :In geographic regions with low dietary exposure to AFB1 codon 249 is rarely affected and, instead, a variety of somatic mutations in TP53 gene may occur as a late event in liver carcinogenesis [63,64]. This hypothesis is supported by the appearance of dedifferentiated cellular subpopulations following the occurrence of TP53 mutations within HCC [65], the occurrence of distinct mutations in nodule-in-nodule HCCs [66], presence of more severe cellular atypia in areas with LOH of TP53 within HCC [64], and finally the high rate of TP53 mutations in moderately to poorly differentiated HCC [67]. Moreover, the spectrum of TP53 mutations is very wide with 75% missense mutations scattered over 200 codons mainly throughout the central portion of the gene affecting the central DNA-binding domain of the encoded protein [35,37].
cDNA microarray analysis of macroregenerative and dysplastic nodules in end-stage hepatitis C virus-induced cirrhosis
2003, American Journal of PathologyChromosomal allelic imbalance evolving from liver cirrhosis to hepatocellular carcinoma
2001, Gastroenterology