Original Articles: General ThoracicTumor angiogenesis and recurrence in stage I non-small cell lung cancer
Section snippets
Patients and methods
Tumor samples were randomly obtained from 104 primary lung cancer patients in stage I who received curative operations with routine systematic nodal dissection of both the hilar and the mediastinal lymph nodes as previously described 7, 8 in Kanazawa University Hospital from 1988 to 1993. In follow-up periods longer than 5 years, 43 patients died from recurrent lung cancer and 61 patients survived without any recurrence. In the recurrent group (n = 43), the 34 men and 9 women had a mean age of
Results
The 3- and 5-year survival rates for the patients in the recurrent group (n = 43) were 34.9% and 14.0%, respectively, having a significantly worse prognosis as compared to those (both 100%) in the nonrecurrent group (p < 0.01).
The percentage of VEGF positive tumors and that of tumors with the strongest VEGF stain (more than 50% of the staining area in tumor cells) were 88.9% (48 of 54) and 29.6% (16 of 54) in adenocarcinomas, 80.6% (25 of 31) and 16.1% (5 of 31) in squamous cell carcinomas, and
Comment
In non-small cell lung cancer, Macchiarini and associates [1] first observed a relationship between neovascularization and metastasis in 1992. In 1994, Yamazaki and associates [2] found that angiogenesis, which was assessed by counting microvessels in lung adenocarcinomas, was positively correlated with the relapse of patients after an operation, and they also suggested that microvessel counts in tumors were associated with the aggressiveness of the tumor. Since then, multi-institutional
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