Case ReportsThe relationship between infliximab treatment and lymphoma in Crohn's disease☆,☆☆
Section snippets
Case reports
Patient 1 was a 62-year-old white man who had a 30-year history of ileocolic CD complicated by perianal fistulas. He required multiple resections, leaving him with an ileorectal anastomosis. He was maintained on therapy with azathioprine, 50–150 mg daily, and concurrent prednisone, 5 mg daily, for 9 years. He had no known extraintestinal manifestations of inflammatory bowel disease (IBD). His medical history was notable for episodic tracheobronchitis in the past and nephrolithiasis in 1981. He
Discussion
Lymphomas, including HD, are not considered common in patients with CD. In fact, HD in CD is extremely rare, with only 10 cases previously reported in the medical literature. Of these 10, 4 cases were of the nodular sclerosing subtype,2, 3, 4, 5 3 showed mixed cellularity (1 of which was suggestive of high-grade NHL after further histological review),6, 7, 8 and 3 were not classified further (Table 2).9, 10, 11
Type of
Acknowledgements
Drs. Bickston and Lichtenstein share first authorship of this article.
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Regression of Hodgkin lymphoma after discontinuation of a tumor necrosis factor inhibitor for Crohn's disease: A case report and review of the literature
2011, Clinical Lymphoma, Myeloma and LeukemiaCitation Excerpt :Although the bulk of medical literature addressing the observed development of hematologic malignancies with TNF inhibition have reported cases of NHL,5,7,8 a few case series and reports have described cases of HL in the setting of TNF inhibition therapy.9-12 Two reports describe the diagnosis of HL within weeks to a few months of initiating therapy with infliximab for inflammatory bowel disease (IBD), which suggests that these were either preexisting cases of HL in the setting of IBD or HL causing symptoms masquerading as IBD.10,11 Other more compelling case reports describe diagnoses of HL after several months of ongoing TNF inhibitor therapy.9,12
Anti-TNF therapy and cancer
2010, Reumatologia ClinicaLymphoproliferative disorders in an inflammatory bowel disease unit
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2021, Geriatric Gastroenterology, Second Edition
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Address requests for reprints to: Fabio Cominelli, M.D., Ph.D., Division of Gastroenterology and Hepatology, University of Virginia Health System, Box 10013, Charlottesville, Virginia 22906-0013. e-mail: [email protected]; fax: (804) 243-6405.
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Dr. Cohen has worked as a consultant to Centocor, Inc. Dr. Cominelli has a grant from Centocor, Inc., to study the incidence of lymphoma among hospitalized patients with Crohn's disease. He is also a member of the speaking bureau for Centocor, Inc. Drs. Cominelli and Bickston are currently clinical trial investigators of CDP571 (CellTech Therapeutic Ltd., Berkshire, England).