Elsevier

The Journal of Pediatrics

Volume 99, Issue 6, December 1981, Pages 887-894
The Journal of Pediatrics

Original article
Recurrent infections and delayed separation of the umbilical cord in an infant with abnormal phagocytic cell locomotion and oxidative response during particle phagocytosis

https://doi.org/10.1016/S0022-3476(81)80011-XGet rights and content

An 18-month-old infant with delayed separation of the umbilical cord and severe recurrent bacterialinfections since the newborn period was found to have depressed polymorphonuclear leukocyte locomotion and oxidative metabolic response to particulate stimuli. Both her polymorphonuclear leukocytes and monocytes demonstrated a markedly delayed chemiluminescence response to zymosan, but there was a normal chemiluminescence response to soluble stimuli, phorbol myristate acetate and calcium ionophore A23187. The patient also had a marked delay in uptake of Staphylococcus aureus and Escherichia coli. The patient's polymorphonuclear leukocytes were normal morphologically, and myeloperoxidase was present in histochemical stains. The dichotomy between normal oxidative response to soluble stimuli and abnormal response to opsonized particulate stimuli, plus abnormal cell locomotion and phagocytosis, suggest an agnormality of cell membrane fluidity or contractility.

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Supported by training grant No. T32 AI 07054 and research grants No. 5R01 AI 0693-15 and No. 2R01 AI 08821-10, National Institute of Allergy and Infectious Diseases, and American Legion Heart Research Professorship.

Presented in part at the International Symposium onInfections in the Immunocompromised Host, June 1–5, 1980, The Netherlands.

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