Original articleRecurrent infections and delayed separation of the umbilical cord in an infant with abnormal phagocytic cell locomotion and oxidative response during particle phagocytosis†
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2020, Molecular ImmunologyCitation Excerpt :The pathogenicity of this Gram-positive bacterium is mostly due to the production of toxins, enzymes or cell-surface proteins (Bestebroer al., 2007; Laarman et al., 2011; Falugi et al., 2013). Effective defense by neutrophils is crucial in the elimination of this pathogen; because people with neutropenia or neutrophil functional alterations are more susceptible to S. aureus infections (Lakshman and Finn, 2001; Abramson et al., 1981). The strategies adopted by neutrophils to manage S. aureus include phagocytosis, oxidative killing, and neutrophil extracellular trap formation (Lu et al., 2014; Beavers and Skarr, 2016; Fuchs et al., 2007).
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2012, Principles and Practice of Pediatric Infectious Diseases, Fourth EditionSubcutaneous infection with S. aureus in mice reveals association of resistance with influx of neutrophils and Th2 response
2011, Journal of Investigative DermatologyCitation Excerpt :These different courses depend not only on the virulence of S. aureus, but also on the strength of the host's defense. At this stage, polymorphonuclear leukocytes (PMNs) and macrophages have been shown to be mandatory to combat S. aureus infection (Gresham et al., 2000; Molne et al., 2000; Anwar et al., 2009), because defects in their recruitment or function result in high susceptibility to soft tissue infections with S. aureus (Abramson et al., 1981; Liese et al., 2000; Segal et al., 2000). However, it is not known why in patients without apparent dysfunctions of PMNs, S. aureus progresses to soft tissue infection in some, whereas remaining locally controlled in others (Dressel et al., 2010).
NORMAL AND IMPAIRED IMMUNOLOGIC RESPONSES TO INFECTION
2009, Feigin and Cherry's Textbook of Pediatric Infectious Diseases, Sixth EditionReversion mutations in patients with leukocyte adhesion deficiency type-1 (LAD-1)
2008, BloodCitation Excerpt :At 10 days of age, she developed omphalitis. She was diagnosed with LAD-1 at 6 years.17,20,24TTT–26 She had subglottic abscess at 10 years, osteomyelitis of the left ankle at 14 years, and extensive colitis with perianal fistula formation at 16 years.
A seven-month-old infant with fever and neutrophilic leukocytosis
1992, The Journal of Pediatrics
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Supported by training grant No. T32 AI 07054 and research grants No. 5R01 AI 0693-15 and No. 2R01 AI 08821-10, National Institute of Allergy and Infectious Diseases, and American Legion Heart Research Professorship.
Presented in part at the International Symposium onInfections in the Immunocompromised Host, June 1–5, 1980, The Netherlands.