Human herpesvirus 7: Another causal agent for roseola (exanthem subitum)☆,☆☆,★
Section snippets
Patients
Seventeen children (nine boys) were studied. Fifteen were seen at Shingu Municipal Hospital and two at Kondo Clinic between November 1991 and July 1993. The mean age was 11.9 months (range, 6 to 26 months). All patients had the typical clinical features of ES, such as fever and rash (detailed information concerning the patients may be obtained from the authors on request). Informed consent for blood sampling was obtained for all children from their parents.
Isolation of HHV-6 and HHV-7
Peripheral blood was collected from
Patient 1 (Table)
An 8-month-old boy visited Kondo Clinic with fever (maximum 38.2° C), which continued for 4 days. A light pink maculopapular rash was seen on the face and trunk on the fifth and sixth days of illness. The infant had no other clinical symptoms or signs.9 We cultured PBMCs from peripheral blood collected on the third febrile day. After 10 days of culture, balloonlike cells were observed, but this cytopathic effect seemed to be less than that caused by HHV-6. The IFA tests using McAbs to HHV-6 and
DISCUSSION
Human herpesvirus 7 was first isolated from CD4+ T lymphocytes purified from PBMCs of a healthy adult,1 and subsequently from a patient with chronic fatigue syndrome.4 However, an association between HHV-7 infection and chronic fatigue syndrome was not found by seroepidemiologic studies,10 and the clinical features of the primary infection of HHV-7 have not been established. We now report that HHV-7 was isolated from a patient who had no antibody to HHV-6 and whose clinical features were
References (16)
- et al.
Identification of human herpesvirus 6 as a causal agent for exanthem subitum
Lancet
(1988) - et al.
Outbreak of exanthem subitum in an orphanage
J PEDIATR
(1991) - et al.
Analysis of a glycoprotein of human herpesvirus 6 (HHV-6) using monoclonal antibodies
Virology
(1990) - et al.
Human herpesvirus type 6 infection (exanthem subitum) without fever
J PEDIATR
(1989) - et al.
Isolation of a new herpesvirus from CD4+ T cells
Proc Natl Acad Sci USA
(1990) - et al.
Human herpesvirus 7: antigenic properties and prevalence in children and adults
J Virol
(1991) - et al.
Human herpesvirus 7 (HHV-7) strain JI: independent confirmation of HHV-7
J Infect Dis
(1992) - et al.
The molecular epidemiological studies of human herpesvirus 6 (HHV-6) in families
J Med Virol
(1994)
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2022, Forensic Science International: ReportsCitation Excerpt :These results suggest prior infection and reactivation of HHV-7. Oral infection through saliva is a common infectious route of HHV-7, and more than 90% of persons are infected by six years of age [1,2,4–9]. Furthermore, primary infection with HHV-7 causes roseola infantum and FS [1,5–7,12].
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From the Department of Pediatrics, Osaka University Medical School, Suita, Osaka, the Kondo Clinic, Toyonaka, Osaka, the Pediatric Clinic, Shingu Municipal Hospital, Shingu, Wakayama, the Department of Virology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, and the Department of Microbiology, Osaka University Medical School, Suita, Osaka, Japan
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Reprint requests: Koichi Yamanishi, MD, Department of Virology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565, Japan.
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0022-3476/94/$3.00 + 0 9/20/54482