Original contributionLow prevalence of monoclonal b cells in Helicobacter pylori gastritis patients with duodenal ulcer☆,☆☆
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Cited by (36)
Recent advances in understanding small B-cell leukaemias and lymphomas
2004, Current Diagnostic PathologyThe gastric marginal zone B-cell lymphoma of MALT type
2000, BloodCitation Excerpt :However, the absence of these factors does not necessarily exclude the diagnosis of lymphoma.88, 89 Because lymphoma represents a clonal outgrowth of cells that have acquired certain genetic alterations, finding a monoclonal B-cell population might provide support for a diagnosis.20-2295-98 A monoclonal population can be revealed by genotype investigations of MALT lymphomas that use the Southern blot or polymerase chain reaction (PCR) technique.
PCR analysis of the immunoglobulin heavy chain gene in polyclonal processes can yield pseudoclonal bands as an artifact of low B cell number
2000, Journal of Molecular DiagnosticsCitation Excerpt :Although most of these studies have focused on the sensitivity of PCR-based methods for assessment of clonality, only a few reports have addressed issues relating to its specificity in a systematic fashion. Nevertheless, some studies have demonstrated instances of false positivity, particularly when small or microdissected specimens are used,18 and in reactive conditions involving extranodal sites such as the stomach and salivary gland.19, 20 The results of our study clearly show a relationship between a paucity of B cell targets and a tendency for generating pseudomonoclonal or pseudo-oligoclonal bands by IgH PCR.
Helicobacter pylori infection in gastric mucosa-associated lymphoid tissue lymphoma
2014, World Journal of GastroenterologyExtranodal and splenic small B-cell lymphoma
2013, Modern Pathology
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Supported by grants from the Délégation a la Recherche Clinique (CHU de Bordeax) and the Region Aquitaine.
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Presented in part at the 86th Annual Meeting of the United States and Canadian Academy of Pathology, Orlando, FL, March 1997.