Original contributionAngiogenesis in carcinosarcomas of the uterus: Differences in the microvessel density and expression of vascular endothelial growth factor between the epithelial and mesenchymal elements☆
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Cited by (41)
The role of multimodal adjuvant therapy for FIGO I-II carcinosarcoma of the uterus: a systematic review
2022, Critical Reviews in Oncology/HematologyCitation Excerpt :This theory is supported by the presence of hybrid cells with epithelial and stromal ultrastructural characteristics (de Brito et al., 1993), expression of epithelial markers on mesenchymal cells (George et al., 1991) and high correspondence of molecular markers in epithelial and mesenchymal components (de Jong et al., 2011; Chen et al., 2017). The epithelial component is considered the driving force, showcased by a higher mitotic index (Emoto et al., 1999),expression of endothelial growth factors (McCluggage, 2002) and frequent lymphovascular invasion (de Jong et al., 2011). Additionally, up to 74–94% of metastases are epithelial (Gonzalez Bosquet et al., 2010; Bitterman et al., 1990; Sreenan and Hart, 1995; Matsuo et al., 2016) and metastatic potential is associated with the epithelial histopathology type (Artioli et al., 2015).
The role of fibroblast growth factor 2 in patients with uterine smooth muscle tumors: an immunohistochemical study
2016, European Journal of Obstetrics and Gynecology and Reproductive BiologyCitation Excerpt :The current WHO classification indicates that a uterine smooth muscle tumor not diagnosed unequivocally as benign or malignant should be diagnosed as STUMP [10]. Leiomyosarcomas are rare, highly aggressive malignant uterine smooth muscle tumors occurring mainly in postmenopausal women [11]. To the best of our knowledge, no study evaluated the immunohistochemical expression of FGF-2 in the complete spectrum of uterine smooth muscle tumors so far.
Prognostic factors in uterine sarcoma
2011, Best Practice and Research: Clinical Obstetrics and GynaecologyCitation Excerpt :Conversely, vascular space involvement was not related to the clinical outcome in other studies.30 The prognostic relevance of vascular endothelial-growth factor (VEGF) and its kinase receptors VEGFR-1 (flt-1) and VEGF R- (flk-2) in uterine sarcoma has not yet defined.34,47,48 Arita et al.48 reported that VEGF and its kinase receptors stained significantly stronger in 39 uterine sarcomas than in normal uterine smooth muscle, with no significant differences among the different histological types.
Immunolocalization of VEGF, VEGF receptors, EGF-R and Ki-67 in leiomyoma, cellular leiomyoma and leiomyosarcoma
2011, Acta HistochemicaCitation Excerpt :Mayerhofer et al. (2004) found that 50% of the uterine LMS were positive for Ki-67, but only 5% expressed VEGF. Emoto et al. (1999) also found that the epithelial elements of the carcinosarcoma showed a statistically significant higher VEGF expression than the mesenchymal elements. The authors suggested that the tumor angiogenesis in epithelial elements might be more active than that of the mesenchymal elements (Emoto et al., 1999).
- ☆
A part of content in this study was announced by the first author as the “Tumor angiogenesis in carcinosarcomas of the uterus” at the Six Biennial Meeting of the International Gynecologic Cancer Society at Fukuoka, Japan, October 22, 1997.
Supported by a grant from the Ministry of Education, Science and Culture, Japan (grant #08771370).