EXCRETION OF THE LIGNANS ENTEROLACTONE AND ENTERODIOL AND OF EQUOL IN OMNIVOROUS AND VEGETARIAN POSTMENOPAUSAL WOMEN AND IN WOMEN WITH BREAST CANCER

doi:10.1016/S0140-6736(82)91507-0

The Lancet

Volume 320, Issue 8311, 11 December 1982, Pages 1295-1299

https://doi.org/10.1016/S0140-6736(82)91507-0 Get rights and content

Abstract

Dietary studies and assays of urinary lignans in postmenopausal women showed that lignan excretion is significantly lower in urine of women with breast cancer than in normal omnivorous and vegetarian women and confirmed that there is a significant correlation between fibre intake and lignan excretion. It is suggested that the precursors of the human lignans enterolactone and enterodiol formed by the intestinal microflora are to be found in fibre-rich foods such as grains, nuts, and legumes. Excretion of equol, which has antioestrogenic properties, was similar in all groups studied and did not correlate with fibre intake, but occasional high values were found in some subjects.

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EXCRETION OF THE LIGNANS ENTEROLACTONE AND ENTERODIOL AND OF EQUOL IN OMNIVOROUS AND VEGETARIAN POSTMENOPAUSAL WOMEN AND IN WOMEN WITH BREAST CANCER

Abstract

J Steroid Biochem

FEBS Letts

Lancet

J Pharmaceut Sci

J Pharmaceut Sci

J Pharmaceut Sci

Tetrahedron Letts

Adv Cancer Res

Clin Chim Acta

Steroids

Tetrahedron Letts

The chemistry of lignans

Lignans in man and animal species

Nature

Excretion, isolation and structure of a phenolic constituent of female urine

Nature

The definite identification of the lignans trans-2, 3-bis(3-hydroxybenzyl)-γ-butyrolactone and 2,3-bis(3-hydroxybenzyl) butane-1,4-diol in human and animal urine

Biochem J

Diet and urinary excretion of lignans in female subjects

Med Biol

The excretion of two new phenolic compounds (180/442 and 180/410) during the human menstrual cycle and in pregnancy

J Steroid Biochem

The excretion of two new phenolic compounds during the human menstrual cycle and in pregnancy

Damage induced in sarcoma 37 with podophyllin, podophyllotoxin, alpha-peltatin, beta-peltatin, and quercetin

J Natl Cancer Inst

Effect of alpha-peltatin, beta-peltatin, and podophyllotoxin on lymphomas and other transplanted tumours

J Natl Cancer Inst

The biological effects and the chemical composition of podophyllin. A review

J Natl Cancer Inst

Response of patients with advanced neoplasms to the intravenous administration of alpha-peltatin

J Natl Cancer Inst

Hydrogen peroxide, catalase, glutathione peroxidase, quinones, nordihydroguaiaretic acid, and phosphopyndine nucleotides in relation to X-ray action on cancer cells

Radiation Res Suppl

Clinical experience with intravenous podophyllotoxin

Proc Am Assoc Cancer Res

An interesting observation on nordihydroguaiaretic acid (NSC-4291; NDGA) and a patient with malignant melanoma: a preliminary report

Cancer Chemother Rep

Clinical investigation of a new podophyllin derivative, epipodophyllotoxin, 4'-demethyl-9(4,6-0-2-thenylidene-β-D-glucopyranoside) (NSC-122819), in patients with malignant lymphomas and solid tumors

Cancer Chemother Rep

Activity of a new glycosidic lignan derivative (VP 16-213) related to podophyllotoxin in experimental tumors

Europ J Cancer

Distribution of anticancer activity in higher plants

Cancer Treat Rep

Types of anticancer agents isolated from plants

Cancer Treat Rep

Wikstromel, antitumor lignan from Wikstroemia foetida var. oahuensis Gray and Wikstroemia uva-ursi Gray (Thymelaeaceae)

J Pharmaceut Sci