ArticlesDuration and intensity of maintenance chemotherapy in acute lymphoblastic leukaemia: overview of 42 trials involving 12 000 randomised children
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2021, BloodCitation Excerpt :Similar to maintenance length, any potential benefit of these therapies is largely based on historical data from older trials when therapy was less intensive and outcomes were poor. Early trials that randomly assigned patients to receive or not receive pulses in maintenance found decreased EFS but similar OS rates and no differences in outcome based on sex.17 Some cooperative groups that successfully eliminated the extra year of maintenance in boys without affecting survival did so using a maintenance backbone that included pulses and IT therapy, whereas others eliminated the extra year of maintenance using a backbone that did not include pulses or IT therapy.
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Writing committee and participants listed at end of article
Copyright © 1996 Published by Elsevier Ltd.