Research LettersPrion immunoreactivity in appendix before clinical onset of variant Creutzfeldt-Jakob disease
References (5)
- et al.
A new variant of Creutzfeldt-Jakob disease in the UK
Lancet
(1996) - et al.
Diagnosis of new variant Creutzfeldt-Jakob disease by tonsil biopsy
Lancet
(1997)
Cited by (292)
Body-first Parkinson's disease and variant Creutzfeldt–Jakob disease – similar or different?
2022, Neurobiology of DiseaseLaboratory Identification of Prion Infections
2022, Encyclopedia of Infection and ImmunityImplications of gut microbiota dysbiosis and metabolic changes in prion disease
2020, Neurobiology of DiseaseCitation Excerpt :Many prion disease are acquired by oral consumption of contaminated food or pasture. PrPSc initially appears in intestinal neurons and gut-associated lymphoid tissues within the intestinal lining, including the tonsils, Peyer's patches, appendix, and colonic and cecal patches, together with the mesenteric lymph nodes (Hilton et al., 1998; Mabbott et al., 2003). The early replication of prions in the intestines has been found to be essential for its spread to the brain (Laura et al., 2011; Montrasio et al., 2000) and the intestinal luminal epithelium is also involved in transportation of PrPSc (Donaldson et al., 2016; Heppner et al., 2001; Marshall et al., 2018), which suggests that the pathogenic agent may cause disorder in the gut environment and thus result in a series of complex alterations to cellular metabolism, which may further intensify prion infection in the brain.
Prion Diseases
2018, Neurologic ClinicsHuman transmissible spongiform encephalopathies: historic view
2018, Handbook of Clinical Neurology