A study of 42 episodes of overwhelming post-splenectomy infection: Is current guidance for asplenic individuals being followed?
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Cited by (103)
Utilizing pharmacy intervention in asplenic patients to improve vaccination rates
2018, Research in Social and Administrative PharmacyCitation Excerpt :Studies have demonstrated that patients post-splenectomy have the best immunologic response to vaccination 2 weeks following surgery.4 Despite these recommendations, literature has found that most asplenic patients do not receive complete vaccinations.5,6 Based on the importance of vaccination and literature demonstrating poor compliance with vaccination guidelines, this institution implemented a pharmacy-driven electronic tracking system.5,6
Asplenic patients and invasive pneumococcal disease—how bad is it these days?
2016, International Journal of Infectious DiseasesCitation Excerpt :In the current study, the pneumococcal infection in the asplenic group was more severe as judged by markers of supportive treatment intensity, which included ICU admission, mechanical ventilation, complications such as meningitis, and acute kidney injury; however, in both absolute and relative terms, the mortality rate was similar to that in those with a spleen. This still represents an improvement in comparison to earlier studies.2,3 Whether this is due to general improvements in the care of very sick patients, partial protection afforded by pneumococcal vaccination, increased ‘herd’ immunity, or other factors is unclear.
Fatal purpura fulminans and Waterhouse-Friderichsen syndrome from fulminant Streptococcus pneumoniae sepsis in an asplenic young adult
2016, IDCasesCitation Excerpt :Streptococcus pneumoniae is the most common cause of sepsis in asplenic patients [2]. Although rates of pneumococcal sepsis have been decreasing since the widespread use of pneumococcal vaccines [3], overall rates of guideline-based post-splenectomy vaccinations and care remain low [4]. Purpura fulminans and Waterhouse-Friderichsen syndrome are rare, life-threatening complications of sepsis.
How I treat autoimmune lymphoproliferative syndrome
2011, BloodCitation Excerpt :Our recommendations for asplenic ALPS patients include life-long daily antibiotic prophylaxis as well as periodic surveillance and reimmunization against pneumococci using a combination of both 13-valent conjugate (Prevnar-13) and 23-valent polysaccharide (Pneumovax) vaccines every 4 to 5 years.64,65 Recently, there has been an increased awareness of some associated morbidity and mortality, including overwhelming postsplenectomy infection, on long-term follow-up of patients after splenectomy for other indications as well.66-68 Thus, splenectomy should be avoided unless it is the only remaining measure to control chronic, refractory, life-threatening cytopenias in ALPS patients.
Current status and perspectives of the future of pancreatic surgery: Establishment of evidence by integration of “art” and “science”
2021, Annals of Gastroenterological Surgery