Complications of treatmentFree radicals and antioxidants in chemotherapyinduced toxicity
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2021, PhytomedicineCitation Excerpt :As many anticancer drugs target DNA in proliferating cells, their side effects are primarily manifested in tissues with high-proliferative cells such as bone marrow and gastrointestinal tract, and result in gastrointestinal toxicity, myelosuppression, and immunosuppression (Hurley, 2002). Further, chemotherapeutic drugs and irradiation are known to induce oxidative stress and inflammatory response, and they are closely associated with chromosomal instability and secondary tumor generation (Vyas et al., 2014; Weijl et al., 1997). Therefore, a better understanding of the mechanisms that underlie the induction of the side effects can facilitate the design of supportive or adjuvant therapies for combating them.
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