Gene expression pattern
Comparison of the expression of three highly related genes, Fgf8, Fgf17 and Fgf18, in the mouse embryo

https://doi.org/10.1016/S0925-4773(98)00061-6Get rights and content
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Abstract

In mammals, 16 members of the Fgf family have so far been described with diverse roles in embryonic cell growth and differentiation. Here, we report the expression from early streak stage to midgestation of two newly-identified murine genes, Fgf17 and Fgf18, that are most closely related to Fgf8 (63.7% and 56.8% identical, respectively, at the amino acid level). Fgf17 is expressed during gastrulation but at lower levels than Fgf8, while Fgf18 RNA is not expressed until later, in paraxial mesoderm. In the developing tail bud, each Fgf gene shows a different pattern of transcription. Distinct and overlapping expression patterns are also described in the developing brain and limbs.

Keywords

Fgf8
Fgf17
Fgf18
Mouse embryo
In situ hybridization
Whole mount
Gastrulation
Neurulation
Somitogenesis
Brain
Limb
Tail bud
Mesoderm
Somites
Midbrain
Hindbrain
Hypothalamus
Otic vesicle
Dorsal root ganglia

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