Hypothesis: cis-unsaturated fatty acids as potential anti-peptic ulcer drugs
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Cited by (17)
Dietary amelioration of Helicobacter infection
2014, Nutrition ResearchCitation Excerpt :Numerous investigators have reported in vitro effects of specific polyunsaturated fatty acids against H pylori[154-156], but studies in humans have been mixed, with some studies showing anti H pylori activity [81,82] and others showing none [154,157]. Anti-inflammatory activity has been reported [158], as has protection against ulcer formation [159], reduced risk of atrophic gastritis [160], and suppression of gastric acid secretion [82,161]. Shorter chain fatty acid activity against H pylori has only been demonstrated in vitro [162,163].
Effects of Fish Oil with a High Content of n-3 Polyunsaturated Fatty Acids on Mouse Gut Microbiota
2014, Archives of Medical ResearchCitation Excerpt :It is evident from the results of the present study that fish oil can suppress the growth of Helicobacter, Clostridiales, Sphingomonadales, Firmicutes, Pseudomonas sp. and several uncultured bacteria. These results are interesting because it is known that Helicobacter play a significant role in the pathogenesis of peptic ulcer disease, whereas Firmicutes in obesity and unsaturated fatty acids may be of benefit in peptic ulcer and obesity (47–56). Based on these results and the present study, it is reasonable to propose that n-3 fatty acids suppress the growth of gut microbiota that are associated with obesity and peptic ulcer disease and enhance the proliferation of beneficial bacteria.
Radiation resistance, invasiveness and metastasis are inflammatory events that could be suppressed by lipoxin A <inf>4</inf>
2012, Prostaglandins Leukotrienes and Essential Fatty AcidsCitation Excerpt :In addition, it was noted that alloxan-induced cytotoxicity to pancreatic β cells was prevented by GLA, AA and to a limited extent by EPA and DHA and PGE1, PGE2, PGI2, PGF1α and PGF3α both in vitro and in vivo [93–96]. These results [23–30,85–96] suggest that some PUFAs and PGs have the capacity to selectively kill tumor cells without harming normal cells, enhance the cytotoxic action of radiation and chemotherapeutic drugs on tumor cells [97] and at the same time protect bone marrow cells, pancreatic β cells and gastric mucosal cells [23–30,85–96,98–101] from radiation and chemical-induced insults. This highly beneficial but paradoxical action of PUFAs in showing cytoprotective action on normal against radiation and chemicals and cytotoxic action on tumor cells need to be understood clearly to device effective, robust, dependable and selective tumoricidal molecules.
Gamma-linolenic acid from fourteen boraginaceae species
2003, Industrial Crops and ProductsPaederia foetida - a promising ethno-medicinal tribal plant of northeastern India
2013, Journal of Forestry Research