Original aricle
Comparative analysis of Light's criteria and other biochemical parameters for distinguishing transudates from exudates

https://doi.org/10.1016/S0954-6111(98)90009-9Get rights and content
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Abstract

Objectives: To compare the accuracy of Light's criteria for categorizing a pleural effusion as an exudate with several alternative criteria.

Design: Prospective evaluation of patients who underwent a diagnostic thoracocentesis.

Setting: Community teaching hospital in Lleida, Spain.

Patients and methods: Medical records and pleural fluid characteristics of 241 consecutive patients with pleural effusion admitted over a 29-month period were reviewed. Forty eight of these patients were excluded for different reasons. Light's criteria and a different cutoff level for the pleural fluid cholesterol level were applied and their accuracies were calculated.

Results: Of the 193 patients included, 38 (20%) had transudates and 155 (80%) exudates. The accuracy of Light's criteria for identifying exudates was 92% [confidence intervals (CI), 88–96%], with a sensitivity of 97% (CI, 94–100%) and specificity of 71% (CI, 57–85%). A cutoff level of 50 mg dl−1 was selected for pleural cholesterol, which yielded a sensitivity and specificity of 84% (CI, 79–90%), with an accuracy of 84% (CI, 72–96%). Overall, pleural cholesterol misclassified more exudates as transudates than Light's criteria (15 vs. 3·2%, P<0·001). The combination of pleural cholesterol with lactate dehydroegnase (LDH) or pleural fluid/serum protein ratio revealed a comparable accuracy to that achieved with Light's criteria.

Conclusions: Light's criteria are just as useful as the association of pleural cholesterol and LDH to detect exudates. In the present study, no parameter, including pleural cholesterol, was superior to Light's criteria.

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