The mRNA 5′ cap-binding protein eIF4E and control of cell growth

doi:10.1016/S0955-0674(98)80150-6

Current Opinion in Cell Biology

Volume 10, Issue 2, April 1998, Pages 268-275

https://doi.org/10.1016/S0955-0674(98)80150-6 Get rights and content

Abstract

Control of gene expression at the translational level is important in cell growth and proliferation. Recent work has identified pathways that transmit signals from extracellular stimuli to several translation components. A key participant in regulation of translation is eIF4E, the mRNA 5′ cap-binding protein. Several signalling pathways impact on the activity of eIF4E. This review will summarise recent findings on the MAP kinase signalling pathway that leads to phosphorylation of eIF4E and on pathways that regulate repression of eIF4E function. A major unresolved question is how the changes in translation modulate cell growth rate, and a working model will be discused.

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The mRNA 5′ cap-binding protein eIF4E and control of cell growth

Abstract

J Biol Chem

Cell

J Biol Chem

J Biol Chem

J Biol Chem

J Biol Chem

J Biol Chem

EMBO J

EMBO J

Nature

Proc Natl Acad Sci USA

Mol Cell Biol

Proc Natl Acad Sci USA

J Biol Chem

Trends Biochem Sci

Nature

Mol Cell Biol

Science

Science

Nature

Genes Dev

Cancer Res

Oncogene

J Biol Chem

mRNA 5′ cap-binding protein eIF4E and control of cell growth

Translational control in mammalian cells

Annu Rev Biochem

Origins and targets of translational control

Initiation of protein synthesis in eukaryotic cells

Eur J Biochem

Structure of translation factor eIF4E bound to m7GDP and interaction with 4E-binding protein

Nature Struct Biol

Cap binding protein complex that restores protein synthesis in heat-shocked Ehrlich cell lysates contains highly phosphorylated eIF-4E

J Biol Chem

Chromatographic resolution of in vivo phosphorylated and nonphosphorylated eukaryotic translation initiation factor eIF-4E: increased cap affinity of the phosphorylated form

Proc Natl Acad Sci USA

Lipopolysaccharide stimulates phosphorylation of eukaryotic initiation factor-4F in macrophages and tumor necrosis factor participates in this event

Second Messengers Phosphoproteins

Heat shock-induced translational alterations in HeLa cells. Initiation factor modifications and the inhibition of translation

J Biol Chem

Insulin-stimulated phosphorylation of initiation factor 4E is mediated by the MAP kinase pathway

FEBS Lett

Involvement of stress-activated protein kinase and p38/RK mitogen-activated protein kinase signaling pathways in the enhanced phosphorylation of initiation factor 4E in NIH 3T3 cells

J Biol Chem