Original articleSinonasal tract seromucous adenocarcinomas: a report of 12 cases
Section snippets
Materials and methods
Twelve cases of sinonasal seromucous adenocarcinoma were retrieved from the files of the Department of Pathology at The University of Texas M. D. Anderson Cancer Center (Houston, TX) covering a period from January 1, 1992 to December 31, 1999. Clinical and surgery reports and follow-up data were examined. In all case, hematoxylin-eosin stained histologic sections were available for review. Two to 18 slides (mean, eight slides) per case were reviewed, and the light microscopic features were
Results
The clinicopathologic findings in the 12 cases reviewed are summarized in Table 1. Patients’ ages ranged from 30 to 87 years (mean age, 56.3 years). Nine patients were white, one Asian, and race was unspecified in two cases. The ratio of men to women was 9:3. The most common presentation was nasal obstruction (six cases), with the remaining patients presenting with mass/sinusitis (four cases) and bleeding (two cases) as the primary complaint. The duration of the symptoms ranged from months to
Discussion
The normal sinonasal mucosa is covered by a pseudostratified columnar ciliated epithelium with goblet cells. The luminal lining of ciliated and goblet cells in varying proportions is separated from flattened basal cells by one or more layers of intermediate cells.7 Beneath the epithelium is the submucosa with the seromucous glands of the nasal respiratory tract, which are referred to as the “glandulae nasals.”7 These glands consist of irregularly branching tubules that often end blindly and
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