Molecules in focus
Thyroid transcription factor-1

https://doi.org/10.1016/S1357-2725(97)00007-1Get rights and content

Abstract

Thyroid transcription factor-1 (TTF-1) is a recently identified member of the homeodomain transcription factor family, which plays a role in regulating genes expressed within the thyroid, lung and brain, including thyroglobulin, thyroid peroxidase, Clara cell secretory protein and the surfactant proteins. Additional studies, including gene targeting experiments, have clearly shown that expression of TTF-1 is essential for morphogenesis of the thyroid, lung and ventral forebrain, as TTF-1 knockout mice lack these organs. In the light of these studies it seems possible that mutations in TTF-1 may underlie certain abnormalities either of organogenesis of, or of cellular function within, these organ systems. A recent example of such a defect is the identification of a patient with thyroglobulin deficiency due to decreased TTF-1 expression.

References (15)

There are more references available in the full text version of this article.

Cited by (121)

  • Epitope mimicry analysis of SARS-COV-2 surface proteins and human lung proteins

    2021, Journal of Molecular Graphics and Modelling
    Citation Excerpt :

    NK2 homeobox 1 is a transcription factor that is expressed in the early development of the lung and thyroid gland [35]. It is also involved in the synthesis of the surfactant proteins A, B, and C [35]. Furthermore, it was found that it regulates the expression of ABCA3 proteins, thus, NKX2-1 is required for the normal structure of surfactant which is important for the alveolar function and lowering the alveoli surface tension [27].

  • Clinicopathological and prognostic significance of thyroid transcription factor-1 expression in small cell lung cancer: A systemic review and meta-analysis

    2019, Pathology Research and Practice
    Citation Excerpt :

    Thyroid transcription factor-1 (TTF-1) was initially regarded as a thyroid-specific gene transcription activator and also known as TITF-1 or Nkx2-1 [4]. It is mainly expressed in the thyroid glands, lungs and brain [5]. In normal adult lungs, it is restricted to express in type II pneumocytes and Clara cells [6]; it has also been reported that TTF-1 plays a crucial role in regulating the expression of several genes such as the Clara cell protein and surfactant [7,8].

  • 57 - Lung Diseases Associated With Disruption of Pulmonary Surfactant Homeostasis

    2019, Kendig's Disorders of the Respiratory Tract in Children
  • TTF-1/Nkx2.1 functional connection with mutated EGFR relies on LRIG1 and β-catenin pathways in lung cancer cells

    2018, Biochemical and Biophysical Research Communications
    Citation Excerpt :

    TTF-1 also termed Nkx2.1 and T/EBP (thyroid-specific enhancer binding protein), plays an essential role in the correct development of the thyroid, lung and forebrain [3]. In the lung of adult animal, TTF-1 expression persists in the terminal respiratory unit (TRU) including alveolar epithelial cells, mainly type II cells, and in Clara secretory cells [3,4]. TTF-1 controls the expression of the Surfactant proteins A, B and C in lung type II cells and Clara secretory protein in Clara cells [5,6].

View all citing articles on Scopus
View full text