Case studyDifferences of immunophenotypic markers and signaling molecules between adenocarcinomas of gastric cardia and distal stomach☆
Section snippets
Patients
Ninety-nine patients with gastric cardiac and distal adenocarcinomas consecutively operated on at Cixian County Hospital and Zanhuang County Hospital in Hebei Province from January 2005 to December 2009 were included in the study. All patients underwent preoperative upper gastrointestinal endoscopies (with biopsy specimens routinely performed). Fifty patients with cardiac carcinoma attended in this study were chosen carefully according to the definition of Siewert II AEG, whose tumors' centers
Expressions of CK and MUC in adenocarcinomas of gastric cardia and distal stomach
Tumor tissues derived from 2 subsites were characterized by immunohistochemistry, and the malignant cells of carcinomas showed reactivity for the antigens under study (Fig. 2). In all cases, 93.9% of tumors had CK19-positive staining, whereas CK14-positive reactivity was observed in only 20 cases (20.2%). Among 99 cases with cardiac and distal cancers, the positive expressions of CK7, CK20, MUC1, MUC2, and MUC5AC were detected in 82 (82.8%), 48 (48.5%), 59 (59.6%), 61 (61.6%), and 69 (69.7%)
Discussion
The reason for the increasing incidence of cardiac adenocarcinomas is obscure. Ambiguous definition of these tumors regarding origin or etiology hampers largely diagnosis and treatment for patients. Special immunophenotypic markers may be helpful to comprehend cardiac tumors. Therefore, we detected the expressions of certain CKs and MUCs in adenocarcinomas of gastric cardia and distal stomach. Different immunoreactivity of the antigens in 2 groups may provide us a better understanding about
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This work was supported by Key R & D Project of Hebei Province (No. 07276102D for Xianghong Zhang), Scientific Foundation of Hebei Province Educational Commission (No. ZH200801 for Xianghong Zhang), and the Natural Science Foundation of Hebei Province for Youths (No. 2009001098 for Liying Xue).