Immune deficiencies, infection, and systemic immune disordersInfluence of cytomegalovirus infection on immune cell phenotypes in patients with common variable immunodeficiency
Section snippets
Study populations
Seventy-one patients with CVID (35 male patients; age, 24-86 years; median, 52 years) attending the Royal Free Hospital and 19 healthy subjects (7 male subjects; age, 25-71 years; median, 45 years; P > .05 vs patients with CVID) were analyzed. CVID was defined according to the International Union of Immunological Societies criteria.9, 10 All patients with CVID received standard immunoglobulin therapy, and blood samples for T-cell studies were collected before immunoglobulin treatment. CMV
CMV infection is associated with inversion of the CD4/CD8 T-cell ratio in patients with CVID
The cellular immunologic profiles of the patients with CVID and healthy control subjects are shown in Table I. Differences between patients with CVID and healthy subjects are well documented12, 13, 14, 15; here we separate them according to CMV status. Frequencies of switched memory and transitional B cells and plasmablasts were marginally reduced in CMV-positive patients compared with CMV-negative patients, but these changes were not statistically significant.
CD4 T-cell numbers in patients
Discussion
CVID is the most common clinically relevant primary immune deficiency. A subset of patients experience debilitating inflammatory complications that are strongly associated with CMV infection. We previously described a distinct hyperproliferative CD8+ T-cell phenotype in these patients. In this study we have extended our previous observations to profile the global effect of CMV on immune effector cell populations in patients with CVID, refine our description of the functional phenotype of the CD8
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Cited by (0)
The UCL MRC Centre for Medical Molecular Virology is funded by Centre Grant from the Medical Research Council. Part of this work was funded by a Wellcome Trust Grant (to V.C.E. and colleagues) and a grant from the Primary Immunodeficiency Association (to A.D.W.). S.M.M. received a scholarship from Tehran University of Medical Sciences and was supported by a PhD studentship from the Iranian Ministry of Health.
Disclosure of potential conflict of interest: S. Workman has received honoraria from Octapharma UK. V. C. Emery is on the advisory board and is a speaker for Roche and has received research support from the Wellcome Trust. The rest of the authors declare that they have no relevant conflicts of interest.
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Mohammed Raeiszadeh, MPhil, is currently affiliated with the School of Cancer Sciences, University of Birmingham, Birmingham, United Kingdom.