Renal transplantationComplicationRisk Factors for Urinary Tract Infections During the First Year After Kidney Transplantation
Section snippets
Patients and Methods
This retrospective cohort study was based upon clinical files of patients who received a renal transplant in our center between January 2003 and December 2007, excluding 2 patients who lost their grafts in the first week due to acute antibody-mediated rejection. The primary outcome was the development of UTI, which was defined as the presence of more than 100,000 colony-forming units (CFU) of a pathogenic organism per mL urine. The univariate analysis was performed with chi-square test for
Results
Among the 176 subjects 54.5% were males and the overall average age was 37 ± 12 years. The UTI incidence was of 35.8% (n = 63). The bacterium most frequently found in urine cultures was Escherichia coli (n = 46). Twenty percent (n = 13) of patients who developed UTI displayed acute rejection episodes (P = .85) and 25% (n = 16) had biopsy-proven interstitial fibrosis and tubular atrophy (IF/TA) (P = .77). Upon univariate analysis, the risk factors associated with UTI development in the first
Discussion
In this study, the UTI incidence was 35.8%, which is similar to that reported by other centers. The risk factors associated with the development of UTI were similar to those previously described: age, female gender, posttransplantation genito-urinary alterations, days of bladder catheter placement, and history of UTI in the month prior to the transplantation.1, 2, 3 In our cohort, UTI was not associated with a deleterious effect on graft function. An important observation is that many of these
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Infective complications in renal allograft recipients: epidemiology and outcome
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Significance of pretransplant urinary tract infection in short-term renal allograft function and survival
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