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Relationship Between Grade of Microsatellite Instability and Target Genes of Mismatch Repair Pathways in Sporadic Colorectal Carcinoma

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Abstract

Microsatellite instability (MSI) induces carcinoma through the alteration of target genes; TGF-β RII, BAX, IGFIIR, hMSH3, and hMSH6. The grade of MSI is classified into two categories according to the number of positive microsatellite markers; MSI-H and MSI-L. To elucidate the relationship between the propriety of grading MSI, target genes and clinical features of sporadic colorectal cancers, MSI and frameshift mutation of target genes were examined in 132 colorectal cancer patients. Fourteen and 12 cases showed MSI-H and MSI-L, respectively. Of the 14 MSI-H cases, 13 cases showed alteration of target genes. However, of the 12 MSI-L cases, only one case showed alteration of one target gene. Furthermore, all 14 MSI-H patients had cancers of the right colon and were typically older in age than the MSI-negative patients. These results imply a strong relationship between MSI-H and carcinogenesis by the frameshift mutation of target genes.

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Togo, G., Shiratori, Y., Okamoto, M. et al. Relationship Between Grade of Microsatellite Instability and Target Genes of Mismatch Repair Pathways in Sporadic Colorectal Carcinoma. Dig Dis Sci 46, 1615–1622 (2001). https://doi.org/10.1023/A:1010628831884

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