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Immunohistochemical analysis of prostate specific antigen in breast cancer*

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Abstract

The presence of immunoreactive prostate-specific antigen (IR-PSA) has been reported in breast cancers and has been suggested to confer a positive prognosis. However, recent large, well-controlled studies have found no significant prognostic value when IR-PSA positivity is examined as an independent variable, even when ultrasensitive immunofluorometric techniques are utilized. The present study, using indirect immunohistochemistry on 75 formalin-fixed, paraffin-embedded breast cancers shows PSA immunoreactivity in only seven of 75 cases (9%), suggesting that PSA positivity in breast carcinoma is not useful as a prognostic or tumor marker with hospital-based methods.

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Authors and Affiliations

  1. The Lillian and Henry Stratton-Hans Popper, Deptartment of Pathology, The Mount Sinai Medical Center, New York, NY

    Michael K. Miller, Pamela D. Unger & Ira J. Bleiweiss

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  1. Michael K. Miller
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  2. Pamela D. Unger
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  3. Ira J. Bleiweiss
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Miller, M.K., Unger, P.D. & Bleiweiss, I.J. Immunohistochemical analysis of prostate specific antigen in breast cancer*. Breast Cancer Res Treat 68, 111–116 (2001). https://doi.org/10.1023/A:1011959127928

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