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p53 Protein Accumulation Is a Specific Marker of Malignant Potential in Barrett's Metaplasia

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Abstract

Our aim was to determine the sensitivity andspecificity of p53 accumulation as a marker of malignantpotential in Barrett's metaplasia (BM). One hundredeighty biopsies from 61 patients with BM were evaluated for p53 accumulation by immunohistochemistry.Of 25 patients with LGD, 9 had p53-positive biopsies,and of these 5 (56%) developed HGD/CA, whereas 16 hadp53-negative biopsies and none (0%) developed HGD/CA after similar follow-up times (P = 0.0108). Asa marker of malignant potential in BM, p53 accumulationhas a sensitivity of 100%, specificity of 93%, and apredictive value of a positive test of 0.56, compared to sensitivity of 100%, specificity of 64%, andpredictive value of a positive test of 0.2 for ahistologic diagnosis of LGD. We conclude that: (1) p53accumulation is more specific and has better predictive value for subsequent development of HGD/CA thanhistologic diagnosis of LGD. (2) Patients with LGD andp53-positive biopsies are more likely to develop HGD/CA;therefore, they should be followed up more closely than those with LGD and p53-negativebiopsies.

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Authors
  1. Mamoun Younes
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  2. Atilla Ertan
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  3. Lia V. Lechago
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  4. Jacqueline R. Somoano
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  5. Juan Lechago
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Younes, M., Ertan, A., Lechago, L.V. et al. p53 Protein Accumulation Is a Specific Marker of Malignant Potential in Barrett's Metaplasia. Dig Dis Sci 42, 697–701 (1997). https://doi.org/10.1023/A:1018828207371

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  • DOI: https://doi.org/10.1023/A:1018828207371

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