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Impact of Oncogenes and Tumor Suppressor Genes on Deregulation of Hemostasis and Angiogenesis in Cancer

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Abstract

We postulate that oncogenes and tumor suppressor genes may influence tumor angiogenesis not only directly (e.g. by upregulating vascular endothelial growth factor) but also through their impact on expression (and/or function) of tissue factor and other elements of the hemostatic system.

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Authors and Affiliations

  1. Hamilton Civic Hospital Research Centre, McMaster University, Hamilton, Ontario

    Janusz Rak

  2. Sunnybrook and Womens College Health Science Centre, University of Toronto, Toronto, Canada

    Giannoula Klement

Authors
  1. Janusz Rak
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  2. Giannoula Klement
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Rak, J., Klement, G. Impact of Oncogenes and Tumor Suppressor Genes on Deregulation of Hemostasis and Angiogenesis in Cancer. Cancer Metastasis Rev 19, 93–96 (2000). https://doi.org/10.1023/A:1026516920119

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  • DOI: https://doi.org/10.1023/A:1026516920119

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