Abstract
A number of proto-oncogenes have recently been localized to the chromosomal segments that are the breakpoints in the specific rearrangements noted in human malignant diseases1. Moreover, rearranged forms of several proto-oncogenes have been identified in malignant cells; in several instances, the proto-oncogene has undergone an alteration as a result of a nonrandom chromosomal rearrangement2–4. One proto-oncogene that has yet to be associated with human neoplastic disease is c-src, the cellular homologue of the transforming sequence of Rous sarcoma virus (RSV). By somatic cell hybridization, c-src has been mapped to chromosome 20, but its precise location was not determined5. We have now mapped this gene by using in situ hybridization of the cloned human c-src probe to human mitotic chromosomes. We report here that the human genome contains two loci with strong homology to the coding regions of this oncogene, at Ip34–p36 and 20ql2–ql3. It is noteworthy that these chromosomal regions are frequently involved in the structural rearrangements observed in haematological malignant diseases6–8.
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Le Beau, M., Westbrook, C., Diaz, M. et al. Evidence for two distinct c-src loci on human chromosomes 1 and 20. Nature 312, 70–71 (1984). https://doi.org/10.1038/312070a0
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DOI: https://doi.org/10.1038/312070a0
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