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cDNA sequence of human apolipoprotein(a) is homologous to plasminogen

Abstract

Lipoprotein(a) is an LDL-like lipoprotein whose concentration in plasma is correlated with atherosclerosis. The characteristic protein component of lipoprotein(a) is apolipoprotein(a) which is disulphide-linked to apolipoprotein B-100. Sequencing of cloned human apolipoprotein(a) complementary DMA shows that it is very similar to human plasminogen. It contains a serine protease domain and two types of plasminogen-like kringle domains, one of which is present in 37 copies.

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McLean, J., Tomlinson, J., Kuang, WJ. et al. cDNA sequence of human apolipoprotein(a) is homologous to plasminogen. Nature 330, 132–137 (1987). https://doi.org/10.1038/330132a0

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