The mammalian cell cycle is controlled by systems that monitor the cell's health and act through the tumour-suppressor p53 and its effector, p21. Therapeutic intervention can restore order to tumour cells lacking p53.
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Jacks, T., Weinberg, R. Cell-cycle control and its watchman. Nature 381, 643–644 (1996). https://doi.org/10.1038/381643a0
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DOI: https://doi.org/10.1038/381643a0
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