Abstract
We have identified an interferon-like cytokine, limitin, on the basis of its ability to arrest the growth of or kill lympho–hematopoietic cells. Limitin strongly inhibited B lymphopoiesis in vitro and in vivo but had little influence on either myelopoiesis or erythropoiesis. Because limitin uses the interferon α/β receptors and induces interferon regulatory factor-1, it may represent a previously unknown type I interferon prototype. However, preferential B-lineage growth inhibition and activation of Janus kinase 2 in a myelomonocytic leukemia line have not been described for previously known interferons.
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Acknowledgements
This work was supported in part by grants from the Yamanouchi Foundation for Research on Metabolic Disorders, the Kowa Life Science Foundation, the Ministry of Education, Science and Culture of Japan and the Japan Society for the Promotion of Science as well as grants AI-33085 and AI-20069 from the National Institutes of Health.
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Oritani, K., Medina, K., Tomiyama, Y. et al. Limitin: An interferon-like cytokine that preferentially influences B-lymphocyte precursors. Nat Med 6, 659–666 (2000). https://doi.org/10.1038/76233
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DOI: https://doi.org/10.1038/76233
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