Elsevier

Modern Pathology

Volume 14, Issue 11, 1 November 2001, Pages 1183-1186
Modern Pathology

Article
Metaplastic Carcinoma of the Breast: p53 Analysis Identified the Same Point Mutation in the Three Histologic Components

https://doi.org/10.1038/modpathol.3880456Get rights and content
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Abstract

A rare case of metaplastic carcinoma of the breast with both squamous metaplasia and cartilaginous metaplasia was reported. Histologically, the neoplasm revealed complex features, which were consisting of invasive ductal carcinoma, squamous carcinomatous component and chondrosarcomatoid component. Gradual transition of each component was recognized microscopically. p53 mutation analysis disclosed the same point mutation in three histologically different components, but not in the normal epithelium. Based on the morphologic findings, immunohistochemical findings and the p53 mutation analysis, we concluded that these three components in the tumor originated from the same duct progenitor cells.

Keywords

Breast cancer
cartilaginous metaplasia
Metaplastic carcinoma
p53
Squamous metaplasia

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